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It has been observed that high scrotal temperatures might result genetic and morphological damage, such as DNA damage, decreased sperm viability, and altered steroidogenesis (126)

Common side effects may include skin irritation, redness, and dryness at the application site

The GD group showed a high abundance of beneficial genera such as Akkermansia , Ruminococcus , Faecalibacterium , and Lactobacillus , well-established producers of SCFAs

The tumour sizes and tumour weight in GNCsiRNA group were smallest among all groups (Fig
