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Nrf2 signaling, an important regulator of antioxidant defense, is impaired during aging [60], leading to reduced levels of antioxidant enzymes like CAT or SOD [62]

Apparently, elderly people are more vulnerable to chronic stress that determines among other parameters, the age-related dynamics in the hepatic CYP-dependent drug metabolism and therefore, the drug efficacy and toxicity (99)

Resveratrol inhibits growth of experimental abdominal aortic aneurysm associated with upregulation of angiotensin-converting enzyme 2

Excess S-adenosylmethionine reroutes phosphatidylethanolamine towards phosphatidylcholine and triglyceride synthesis

Numerous clinical and preclinical studies suggest that gut dysbiosis may contribute to epilepsy development [80, 81]
