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Description
BH4 mitigates ferroptosis by specifically protecting phospholipids containing two polyunsaturated fatty acyl chains (Kraft et al., 2019)
5 Image credit: Champaneri S, Xu X, Carnethon MR, et al
W.WangC.ZhouY.HouM
10.1007/s11940-003-0017-9 Curr
During ferroptosis, when cancer cells are under ROS-induced stress and the antioxidant defense is dysfunctional in the tumor cellular environment, cancer cells shift energy from the OXPHOS pathway to the glycolysis pathway to support vital biological events such as macromolecular biosynthesis, membrane-protein integration and to maintain cross-membrane ion gradients and DNA replication [96]
