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In Se-deficient patients, Se supplementation (typically 200 g/day) has been associated with improved clinical outcomes, including reducing the severity of hypothyroid symptoms and decreasing the need for levothyroxine therapy [22]

Together, these findings illustrate that Mn homeostasis is not static but is dynamically reshaped by disease, reflecting adaptive and maladaptive responses across organ systems

This reduction in receptors in turn will decrease the cells sensitivity to an agonist or drug

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