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A value of 100% for the predefined critical effect sizes represents a two-fold change, which was also used in the present study to define a biologically relevant effect in the in vitro comet assay thus compensating for data variability and avoiding potentially false-positive results
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HGF gene therapy employing naked plasmids succeeds in preventing neuronal death in animal models of ALS (Sun et al., 2002) and PD (Koike et al., 2006, 2009) and induces analgesic effects in a neuropathic pain model (Nho et al., 2018)
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