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Notably, M1 macrophages are more resistant to ferroptosis than M2 macrophages, largely because of elevated levels of inducible nitric oxide synthase (iNOS) (Kapralov 2020)

(PubMed) Sanyal AJ, Chalasani N, Kowdley KV, et al

in this case, the negative regulation of ferroportin by hepcidin is believed to be responsible for the iron deficiency [26,27]

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