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By contrast, PIF4 assembles into nuclear spheres with very low internal mobility, as shown by FRAP, and recovery is insensitive to moderate temperature increases (Fig

Ferroptosis has attracted much attention recently in the area of neurodegeneration since the involvement of ferroptosis in Parkinsons disease (PD), a major neurodegenerative disease, has been indicated using animal models

5,6 For example, free radicals play a role in detoxification of xenobiotics by oxidizing enzymes, in killing of microorganisms by macrophages and cytotoxic lymphocytes, and in the generation of prostaglandins and leukotrienes, which activate oxygenases (e.g., cyclooxygenases and lipoxygenase) and thus act as modulators of the inflammatory response

Renal normothermic machine perfusion: the road toward clinical implementation of a promising pretransplant organ assessment tool