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When levels drop, the effects can be wide-ranging and often mistaken for everyday stress or ageing

Protocols typically involve 10 to 40% reductions in total energy intake compared to ad libitum-fed controls, but with adequate nutrition and a controlled physical environment (2)

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In some cases of pernicious anemia, parietal cell auto-antibodies lead to the destruction of IFproducing parietal cells in the stomach resulting in B12 malabsorption, and thus deficiency