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doi: 10.1210/en.2004-1520 87 ThalerJPYiCXSchurEAGuyenetSJHwangBHDietrichMOet al

The importance of this antioxidant pathway is illustrated in Nrf2 knockout mice in which lung neutrophil inflammation and pulmonary emphysema were evident as early as 8 weeks after cigarette smoke exposure, whereas wild-type mice showed no lung changes at 16 weeks

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