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Am J Physiol 266 C367C375 Avissar N, Finkelstein JN, Horowitz S, Willey JC, Coy E, Frampton MW, Watkins RH, Khullar P, Xu YL, Cohen HJ 1996 Extracellular glutathione peroxidase in human lung epithelial lining fluid and in lung cells
The theory hypothesizes that aging is associated with structural impairment caused due to the accumulation of oxidative damage to crucial macromolecules (lipids, DNA, RNA, and proteins) brought about ROS and RNS (Liguori et al., 2018)

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Nanoparticles for brain drug delivery
Disruption of ROS homeostasis can have profound impacts on cell survival, function, and adaptation [101, 534]