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Description
For example, age-associated increases in DNA damage activates NAD+-dependent PARP1, 63,64 and although PARP1 is a critical DNA repair enzyme, its persistent activation is harmful due to this contribution to NAD+ depletion

for insulin resistance in the elderly

Xiao Z, La Fontaine S, Bush AI, Wedd AG (2019) Molecular mechanisms of glutaredoxin enzymes: versatile hubs for thiol-disulfide exchange between protein thiols and glutathione

Moreover, a study published in Antioxidants found that individuals with high alcohol intake had markedly lower glutathione levels compared to moderate or non-drinkers

Biomaterials 34 (28), 65486558
