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When a connective target suffers severe mechanical trauma, the resulting micro-tears rapidly drop local oxygen tension, creating an ischemic cellular environment

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10.1016/j.jconrel.2010.01.019 CrossRef Google Scholar View reference in article 58 KhafagyE.-S.MorishitaM.IsowaK.ImaiJ.TakayamaK

At helix 23 residues L959 and K955, binding saturation was observed as peaks completely disappeared at 10 M of the peptide