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The emerging role of polyphenols in the management of type 2 diabetes

Oral administration of the CTB-hGAA lyophilized plant cells suppressed GAA-specific IgG1 and IgG2a antibody formation at greater than 10,666-fold lower dose (tobacco leaves containing approximately 0.06mg/kg or 1.5 ug CTB-GAA per mouse) compared to feeding with nonencapsulated rhGAA without CTB fusion (0.64g/kg or 16 mg per mouse) due to improved CTB mediated uptake by the mucosal lining [46, 161]

Immunobiology 172 , 151156 (1986)

Endothelial cell injury due to copper-catalyzed hydrogen peroxide generation from homocysteine

IGF-1 and growth hormone receptor activation controls confirming that AOD-9604 does not engage the classical hGH receptor or elevate IGF-1, distinguishing its mechanism from full-length growth hormone in cell-based reporter systems