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In nasopharyngeal cancer, sulforaphane upregulates miR-124-3p, which directly targets STAT3 signaling and reduces cancer stem cell markers, including -catenin, Nanog, and Oct3/4 in HONE1, SUN1, CNE1, and CNE2 cell lines (125)
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Ferroptosis and exposure to metals/pesticides amplify oxidative injury via Fenton chemistry, glutathione depletion, and GPX4 inhibition
