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Although increased GLR1 activity may be rationalized considering the increase of the GSSG substrate, the reason of the enhanced activity of GSH1 in CO23RFLC strain remains still unexplained (see Discussion)

Jaganjac M, Milkovic L, Sunjic SB, Zarkovic N (2020) The NRF2, Thioredoxin, and glutathione system in tumorigenesis and anticancer therapies

& Demaurex, N

Impairment of ULK1 sulfhydration-mediated lipophagy by SREBF1/SREBP-1c in hepatic steatosis

Consistently, in patients with mutations in the N-acetyl transferase ( NAT ) gene, which is involved in the metabolism and detoxification of free radical species, age-related hearing loss occurs more frequently than in healthy subjects [24]