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Complementary findings demonstrated that systemic immune activation via LPS in mice produced sustained reductions in novel object exploration for up to 24 h ( 3.2.4 Developmental and drug-induced microbiome disruption Disruptions to the gut microbiome during early development or the initial phases of psychiatric illness may influence the trajectory of mental disorders (Lavebratt et al., 2019) reported that early-life antibiotic exposure is linked to modestly increased risks for several childhood psychiatric disorders, including mood disorders, suggesting sensitive developmental windows for microbiome perturbations (Lavebratt et al., 2019)

Intranasal Oxytocin Increases Positive Communication and Reduces Cortisol Levels During Couple Conflict