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This result suggests that increasing copy number was shown to be effective up to a certain limit of gene copy number

Fumarate induces redox-dependent senescence by modifying glutathione metabolism

The technical limitations of the study include that the number of labeled metabolites that can be visualized by MSI is smaller than that measurable by LCMS and that the signal for higher-order labeling (e.g., M4 in citrate and malate) is poor in MSI

Drugs Dermatol 13 , 111118 (2014)

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