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The presence of folate receptor- autoantibodies represents a biologically defined ASD endophenotype with higher responsiveness to folinic acid, illustrating the value of biomarker-guided intervention

In conditions like Long COVID and ME/CFS, the body's ability to generate and utilize energy becomes profoundly dysregulated

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L-carnitine is naturally produced by the body and present in dietary meat sources

Taken together, these heterogeneous findings highlight both biological plausibility and the methodological constraints that shape the current evidence base, motivating the integrative Discussion below