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Unlike antagonists, agonist pharmacoperones do not need to dissociate from the receptor protein after rescue, albeit the potential problem of promoting receptor desensitization and internalization should be considered since this may provoke decreased response to the endogenous ligand

elegans a suitable and convenient in vivo model to identify obesity-promoting compounds or to assess the lipid-lowering capacity of natural products, which could facilitate the prevention of obesity and the identification of potential anti-hyperlipidemic drugs [21,22]

Nielsen AB, Jensen HE, Leifsson PS: Immunohistochemistry for 2',3'-cyclic nucleotide-3'-phosphohydrolase in 63 bovine peripheral nerve sheath tumors

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Our results regarding the hypolipidemic properties of L-carnitine were in accordance with the findings of recent meta-analyses, addressing the ameliorating effects of L-carnitine on TG, TC, LDL-C, and HDL-C (69)