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A number of underlying mechanisms have been proposed, including increased oxidative stress, disruption of normal hormonal and neurological signaling, impaired cellular and mitochondrial processes, formation of abnormal proteins, and DNA damage

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Research cited by Gameday Mens Health found that oral vitamin B12 absorption was limited to just 50% at low dosages and only 1% at higher dosages, while injected B12 reaches the bloodstream at nearly 100% bioavailability