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While these results are exciting and suggest that CuES treatment may be a viable treatment strategy for disorders of copper metabolism, whether CuES will be useful for the treatment of Menkes disease likely will rely on early detection as neocortical and cerebellar Atp7A levels peak early in development (Niciu et al., 2006), as it has been suggested that treatment of Menkes disease patients should commence within 10 days of birth due to the early onset of disease (Kaler, 2013)