glutathione stransferase deficiency Overexpression of S-Transferases in Human Diseases: Drug Targets and Therapeutic Implications Glutathione Participation in the Prevention
Description
He R, Cui M, et al
The pyruvate generated from glycolysis is actively transported into the mitochondria via mitochondrial pyruvate carrier 1 (Rose et al., 2020)
Animal studies have further confirmed that TFRC deletion in mice significantly suppresses TGF-1-induced Fe 2+ accumulation and fibroblast activation, and effectively alleviates bleomycin-induced fibrotic changes in the lungs (Pei et al., 2022)
J Cell Biol 221
doi: 10.1186/s42466-022-00222-8, 81
