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Additionally, trials of oligonucleotide therapeutics and some small-molecule NNMT inhibitors in vitro and in preclinical animal models have validated NNMT as a promising therapeutic target to prevent or treat obesity and related T2D, but currently, clinical trials have not yet been reported

Keith Lafferty MD, Fort Myers on October 10, 2025

Since vitamin B12 is water-soluble, any excess is naturally eliminated by the body, significantly lowering the risk of toxicity

Epigenetics Basics: How NNMT Fits In Epigenetics refers to heritable changes in gene expression that do not involve alterations in DNA sequencecommonly involving DNA methylation , histone modification , or noncoding RNA regulation

Numakura et al