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Animal models support this bottom-up mechanism of disease initiation (Turco et al., 2023)
[DOI] [PMC free article] [PubMed] [Google Scholar] 75.Markovic J., Borrs C., Ortega ., Sastre J., Via J., Pallard F.V
doi: 10.1016/j.jss.2008.08.016
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Mesencephalic astrocyte-derived neurotrophic factor (MANF), an ER stress-responsive protein, has demonstrated neuroprotective effects by inhibiting ER stress in PD models(Kovaleva et al
