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During iron limitation, TTP is upregulated and binds to AU-rich elements of mRNA 3-UTRs, promoting decay of mRNAs encoding lipoic acid synthase (LIAS) , ACO2, NADH:ubiquinone oxidoreductase core subunit S1 (NDUFS1), and ubiquinol-cytochrome c reductase, Rieske iron-sulfur polypeptide 1 (UQCRFS1) , all of which support mitochondrial OXPHOS [48]

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