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In another study using HT22 cells, huperzine A (HupA) + wortmannin treatment stopped the downregulation of p-mTOR, p-Akt, and p-p70s6 kinase under oxidative glutamate toxicity, leading to the conclusion that HupA abrogates oxidative glutamate toxicity in mouse hippocampal cells via the activation of the BDNF/TrkB-dependent PI3K/Akt/mTOR signaling pathway 51

Importantly, inhibition of -oxidation or mitochondrial ATP-synthesis restored ferroptosis sensitivity in VHL reconstituted cells

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Casadesus et al., Brain energy rescue: an emerging therapeutic concept for neurodegenerative disorders of ageing
