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According to the American Diabetes Association and the European Association for the Study of Diabetes, metformin therapy, together with lifestyle intervention, should be initiated at the time of diagnosis of type 2 diabetes

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However, basal levels of phase I and most phase II drug metabolizing enzymes in HepG2 cells are very low compared to human hepatocytes (Wilkening et al., 2003

[DOI] [PMC free article] [PubMed] [Google Scholar] Souza JM, Peluffo G, Radi R

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