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Mechanistic studies revealed that both BFP60 and BFP80 significantly suppressed nitric oxide (NO) production and the secretion of key pro-inflammatory cytokines (IL-6, IL-1, TNF-, and IFN-) (Gu et al., 2022)
[DOI] [PMC free article] [PubMed] [Google Scholar] Vanderauwera S., Zimmermann P., Rombauts S., Vandenabeele S., Langebartels C., Gruissem W., Inz D., Van Breusegem F

This suggests that a high intake of saturated fats and animal protein may contribute to redox imbalance and the development of autoimmunity
It is worth noting that the study identified a ctDNA molecularly defined subgroup of patients (RAS/BRAF/EGFR ECD-mutation negative) for whom prior anti-EGFR therapy had failed and Sym004 had improved OS by 5.5 months (Montagut et al., 2018)
