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Moreover, the infection has been demonstrated in a systematic mechanistic way to promote the TAK1-HSC70 signaling axis to promote the lysosomal degradation of GPX4, which is a process related to the chaperone-mediated autophagy pathway (49)

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Another challenge is that only a subset of TNBCs exhibiting EMT, which represents ~50% of TNBC cases, are vulnerable to eradication through cysteine depletion therapy (27)