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Notably, ellagic acid was found to induce an increase in the expression of beige markers in WAT, such as differentiation cluster 137 and transmembrane protein 26 (60, 61)

This is due to the properties of chelation (binding) and antiradical activity

[DOI] [PMC free article] [PubMed] [Google Scholar] 156.Izzo L.T., Trefely S., Demetriadou C., Drummond J.M., Mizukami T., Kuprasertkul N., Farria A.T., Nguyen P.T.T., Murali N., Reich L., Kantner D.S., Shaffer J., Affronti H., Carrer A., Andrews A., Capell B.C., Snyder N.W., Wellen K.E

In addition, in AD brain both 20S and 19S proteasomal complexes are targets of ox-PTMs, including the formation of HNE adducts, carbonylation, S -glutathionylation, glycoxidation, as well as ADP-ribosylation and phosphorylation (346, 355, 356)