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22 , 23 , 56 Treatments such as antibiotics, proton pump inhibitor medications, antihyperglycemic medicines (eg, metformin), nitrous oxide anesthesia, a nonsteroidal anti-inflammatory drug, some anticonvulsants, and colchicine interfere with B 12 absorption and metabolism

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Nevertheless, outbreaks of pellagra still occur where cereals are not fortified and diets are restricted
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