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With a limited sample size available and the low prevalence of these polymorphisms in this NS5A inhibitor-naive population, it is difficult to determine the true impact of such polymorphisms on treatment outcome
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ALT correlated with TG C56, C58, TG DB7 and DB8 (Table S6)

Deletion of Slc6a14 reduces cancer growth and metastatic spread and improves survival in KPC mouse model of spontaneous pancreatic cancer

[197] [199] Upon entering the presynaptic neuron, amphetamine provokes the release of Ca 2+ from endoplasmic reticulum stores, an effect that raises intracellular calcium to levels sufficient for downstream kinase-dependent signalling
