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doi: 10.1128/jcm.03044-13 127 FuC.ZhangX.VeriA

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It has been estimated that approximately one-third of AAS users may develop a dependence syndrome, characterized by withdrawal symptoms and continued use despite awareness of negative health or social consequences (62)

Two aspects of great importance to the pathophysiology discussed in this article are as follows: ( 1 ) -glutamylcysteine synthetase, the enzyme driving the first reaction, is normally inhibited by physiologic concentrations of the downstream product glutathione (this inhibition is shown by the broken blue line in Figure 1)