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5) Inflammation High TMAO levels were associated with higher levels of TNF-alpha, an inflammatory cytokine, but not with IL-6 or CRP, in 271 adults [24]

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In arteries, more TMAO leads to an increased deposition of cholesterol from the blood, which can lead to atherosclerosis

doi:10.1080/03007995.2017.1292230 Tiequn B, Guanqun C, Shuo Z