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Vitamin D and the omega-3 fatty acids control serotonin synthesis and action, part 2: Relevance for ADHD, bipolar disorder, schizophrenia, and impulsive behavior

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After being decarboxylated, SAMe donates an aminopropyl group to synthesize polyamines, specifically spermidine and spermine

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Additionally, proteins such as acetyl CoA carboxylase (ACC), acyl-CoA synthetase long-chain family member 4 (ACSL4), lysophosphatidylcholine acyltransferase 3 (LPCAT3), and lipoxygenases (LOX) influence PUFA metabolism and oxidation, while glutathione peroxidase 4 (GPX4) fulfills a crucial role in the antioxidant system by directly converting lipid hydroperoxides to lipid alcohols [16, 17]