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360 Owing to its expression and activity increase with age, CD38 is essential for age-associated NAD + decrease through degradation of NMN in vivo

Moreover, Nrf2 has been shown to directly interact with the promoter region of the mTOR gene and enhance its transcription, or it can increase the transcription of upstream mTORC1 activators, such as RagD, a small GTPase protein that is crucial for lysosomal mTORC1 localization (Gureev et al., 2020

Avissar-Whiting, M

Puerarin inhibits high glucose-induced ferroptosis in osteoblasts by modulation of the SLC7A11/GPX4 axis