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It would therefore be conceivable that development of ligands capable of specifically activating signalling complexes with the least capacity to trigger the regulatory mechanisms underlying tolerance could result in more prolonged analgesic actions than those of currently available opioids

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In short, DDSP enables an interpretable and modular approach to generative modeling, without sacrificing the benefits of deep learning

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[DOI] [PubMed] [Google Scholar] Cox EJ, Rettie AE, Unadkat JD, Thummel KE, McCune JS, Paine MF (2022) Adapting regulatory drug-drug interaction guidance to design clinical pharmacokinetic natural product-drug interaction studies: a NaPDI Center recommended approach