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Applying type I PRMT inhibitor GSK3368715 can inhibit PRMTS-mediated epigenetic modification of IFN genes, increase the response of IFN genes to immune signals, and reduce the expression of VEGF in immunosuppressive cells

China Patent Application CN105410629 (A) Maeda H, Hori S, Ohizumi H, Segawa T, Kakehi Y, Ogawa O, Kakizuka A (2004) Effective treatment of advanced solid tumors by the combination of arsenic trioxide and L-buthionine-sulfoximine

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References Hatfield, D
