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Ghosh A, Roy A, Liu X, Kordower JH, Mufson EJ, Hartley DM, Ghosh S, Mosley RL, Gendelman HE, Pahan K (2007) Selective inhibition of NF-kappaB activation prevents dopaminergic neuronal loss in a mouse model of Parkinsons disease

The result indicates that the overall pathway is feasible but acetate kinase (AckA) is the limiting step (Figure 4)

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This is first clinical study demonstrating that a TfR antibody can deliver the enzyme IDS across the BBB into the brain for treatment of Hunter syndrome (mucopolysaccharidosis type II)

However, evidence suggests that this process may be reversible, making it a potential therapeutic target for mitigating renal injury (7173)