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Ultimately, extrapolating findings from animal models of neurodegeneration to humans is complicated by differences in disease chronology and etiology

PMC 387880

Additionally, the activation of microglia and astrocytes in ALS leads to the production of ROS and pro-inflammatory cytokines, further exacerbating oxidative damage and motor neuron degeneration [170]

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Arch Biol Sci 69(3):439448 Austin L, Arthur H, de Niese M, Gurusinghe A, Baker MS (1988) Micromethods in single muscle fibers: 2