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As we identified GPX4 as a functional target of three out of four senolytic chloroacetamides, we wanted to understand how widely senolytic electrophilic compounds might induce ferroptosis

Improved gut inflammation often comorbid with fibromyalgia

By regulating glutathione S-transferase (GST) and intracellular glutathione (GSH) levels, Nrf2 controls the level of ROS in the cell induced by external stressors such as xenobiotic or electrophilic stress

Additionally, the exogenous administration of melatonin has been shown to increase the expression of suppressors of cytokine signaling, thus enhancing the immune response and contributing to the anti-aging effects of this compound (Tresguerres et al., 2012