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Regulation of H 2 S and RSS levels The reactivity of H 2 S and related RSS demands a tight control of their levels, which is ensured both by an intricate regulation of their synthesising enzymes and through an efficient sulphide detoxification pathway located in mitochondria

Inspection of the brain and cerebrospinal fluid of PD patients by sensitive sandwich enzyme immunoassay found an apparently higher level of tumor necrosis factor (TNF), which links extrinsic apoptosis with dopaminergic neuronal death in PD (Mogi et al., 1994)

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