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Monotherapy data suggests cagrilintide is effective at 2.4 mg weekly and retatrutide at 8-12 mg weekly, but these doses cannot simply be combined without understanding potential interactions

Its principal physiological roles are regulation of postprandial glucose excursions and control of energy intake: amylin slows gastric emptying, inhibits post-prandial glucagon secretion and acts on hindbrain/hypothalamic centres to promote satiety, thereby complementing insulin in maintaining glucose homeostasis

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Disclosure of interest: Marlies Wagner: nothing to disclose

Microbial size, the presence of virulence factors, defects in host barrier integrity, along with the active uptake and presentation of luminal antigens by cells of the intestinal epithelium are among the factors that contribute to bacterial translocation (Wolochow et al