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There was also a negative relationship between the total sulphate and glucuronide conjugates and the other metabolites, indicating that if the estrogens are not biotransformed, they are converted into sulphate or glucuronide conjugates, which agrees with the current understanding of estrogen biotransformation

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A multidisciplinary strategy is essential for effective ID-ADC development, integrating medicinal chemistry and bioinorganic techniques to create stable conjugations and build pathogen-responsive linkers (Kwon, 2021)