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Each symptom was scored on a 4-point scale (0 = absent, 1 = infrequent, 2 = frequent, 3 = constant), yielding a total Symptom Score (SS) ranging from 0 to 30, reflecting overall symptom burden and impact on QoL

Additionally, mRNA with multiple chemically modified poly(A) tails was reported to maintain the translational activity of mRNA more persistently due to increased stability [63]

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397 In a Phase II trial (NCT02420314) for advanced NSCLC, Ascorbate combined with Carboplatin and Paclitaxel inhibited tumor growth through HO generation, iron modulation (higher transferrin linked to improved PFS), and immune activation (4.2-fold increase in CD8 + T cells), achieving a 34.2% response rate and a 12.8-month median OS

It is an oral small-molecule secretagogue that stimulates the pituitary to release more of the bodys own GH by activating the ghrelin receptor