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( 4) Pharmacokinetics and Drug Interactions: It acts as a moderate inhibitor of the CYP2D6 enzyme, necessitating caution with concomitant medications that are CYP2D6 substrates

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Cleavage of the C-terminal NCI domain of type XV collagen results in the production of restin, a molecule shown to possess antiangiogenic properties in vitro by inhibiting bFGF-induced EC migration and in a xenograft carcinoma model in vivo 107,108

It is important to keep in mind, however, that some of these substances may have pharmacological limitations, including the mechanism of drug action, administration route, tolerability, side effects, and proven efficacy, that should be considered before they could be approved for its use in this pathology