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The downregulation of OCTN2 activity and protein expression in the kidney reduces the reabsorption of carnitine in the kidney, leading to a decrease in carnitine availability in the liver and causing hepatic lipid metabolism disorders [260]

The catalytic cycle of Grx2 is also quite similar to Grx1 except that the Grx2SSG intermediate can be reduced by NADPH and TrxRD

Whether the skin microbiome exerts a functional role in linking these two biological processes is still unclear

Melatonin is secreted in darkness by the pineal gland