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Severe vitamin B12 deficiency can lead to memory loss, joint pain, and vision problems, among other complications

-Ketoacids stimulate renal cysteine conjugate -lyase activity and potentiate the cytotoxicity of S-(1,2-dichlorovinyl)-L-cysteine

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It is referred to as one-carbon metabolism because what they have in common is the transfer of one-carbon groups

However, the application is limited by the scarcity of donor tissue, additional trauma to the patient and surgical complications ( The complexity of the bone defect microenvironment makes cells vulnerable to various factors during regeneration and repair, creating substantial challenges for bone healing and clinical implementation of bone tissue engineering