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ROS are generated from a number of sources including leakage of single electrons from respiratory enzymes, environmental stresses (e.g., UV radiation), redox cycling agents (e.g., menadione and paraquat), as well as metal-catalyzed oxidation via exposure to free copper (Cu + ) or iron (Fe 2+ ) [4]

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doi: 10.3390/ANTIOX11051020 7

Unless otherwise prescribed: At the start of treatment, 1 ml of vitamin B12-Depot-Injektopas 1500 g is administered twice a week in the first few weeks after the diagnosis (corresponding to 3000 g hydroxocobalamin acetate)