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Protein methylation: SAM-mediated methylation alters protein activity, stability, and localization, impacting signaling pathways such as histone methylation in gene silencing

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By sequestering excess free iron, FTH helps maintain iron homeostasis and prevents the accumulation of labile iron, which is critical for initiating the lipid peroxidation process in ferroptosis 68

Many researchers have used high-throughput sequencing to explore the correlation between genetic susceptibility factors for IBD and gut microbiota, further elucidating their connection [128, 129]